Evidence for a Noncatalytic Carrier Protein in Cholesterol Biosynthesis
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چکیده
منابع مشابه
Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis.
Squalene and sterol carrier protein of liver plays a general role as a vehicle for cholesterol and its water-insoluble precursors; the carrier protein is essential for enzymic cholesterol synthesis. Liver microsomal enzymes contain a small amount of endogenous carrier protein, which is readily removed by washing or purification of the enzyme. Enzymic conversion to products of a cholesterol prec...
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The search for the elusive Na-K-ATPase-inhibiting natriuretic hormone continues. In this review, evidence is presented that isolating the carrier protein for natriuretic hormone from hypertensive plasma is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12 kDa while the final hormone has a molecular weight of 408 Da. Both compounds in...
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Cholesterol feeding inhibits cholesterol biosynthesis in normal but not in malignant liver tissue. It has been postulated that hepatomas have suffered a specific intracellular deletion of the cholesterol feedback control mechanism, but there is little direct evidence to support this hypothesis. Rats bearing Morris transplantable hepatomas were fed high cholesterol diets for periods of up to 21 ...
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The effect of sterol carrier protein-2 (SCP-2) on dolichol biosynthesis by rat liver microsomes was investigated. cis-Prenyltransferase activity was stimulated 7-fold in the presence of 5 micrograms of purified SCP-2/mg of microsomal protein, which was similar to the increase obtained by adding detergent. The polyisoprenoid pattern obtained in the presence of SCP-2 was the same as that present ...
متن کاملLecture 19 Carrier Protein Structure and Recognition in Peptide Biosynthesis
Carrier proteins in polyketide synthase (PKS) and nonribosomal peptide synthase (NRPS) systems play an important role in syntheses of polyketides and nonribosomal peptides respectively (Figure 1). Carrier proteins are relatively small in size (80−100 amino acids; 8−10kDa) compared to other catalytic domains in a synthase system. The key role of carrier proteins is to serve as an attachment site...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1971
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62553-0